Instruments in our lab

The biointerface lab is equipped with state-of-the-art spectroscopy techniques, sepcifically dedicated to the analysis of sample surfaces and interfaces. We also have a setup for the synthesis of nano-microparticles in highly controlled conditions. If you are interested in accessing any of these instruments, please contact us.

Confocal Raman / fluorescence microscope

Bruker Senterra We have a fantastic Bruker Senterra confocal Raman microscope equipped with 3 lasers (785, 633 and 532 nm), which allows us to analyze a vast range of samples, including biological samples. A special hardware feature removes fluorescence background at 785 nm. Sample maps with approximately 1 micron resolution can be obtained with a computer controlled sample stage, and polarizers and analyzers allow us to take polarized spectra. Additionally, we can measure fluorescence maps using the Olympus optical microscope installed on the instrument. The connection with the MultiRAM allows us to measure spectra with excitation wavelength of 1064 nm too.

Back to Top

NIR FT-Raman spectrometer

Bruker Multiram The Bruker MultiRAM spectrometer is a stand-alone FT-Raman spectrometer with excitation wavelength of 1064 nm. We have connected this instrument to the Senterra microscope via a fiber optic, thus achieving the rare possibility of collecting FT-Raman spectra inside a confocal microscope.

Back to Top

Microcalorimetry of adsorption

TAM III The microcalorimeter TAM III from TA instruments is an amazingly sensitive microcalorimeter of adsorption, which we can use to measure energies of interaction between samples in liquid, solid or gas phase. We have two cells, one to perform isotermal titration calorimetry measures, and another that allows us to measure the heat of interaction between two samples simply by putting them in contact with each other.

Back to Top

IR spectrometer

Bruker Tensor We have a Bruker Tensor 27 IR spectrometer, equipped with both a DTGS and an MCT detector. Several attachments allow us to perform measures specifically at interfaces: multi-pass attenuated total reflectance (ATR), with which we can take spectra of samples in water; grazing-angle ATR (GATR), the best technique to analyze self-assembled monolayers; a diffuse reflectance (DRIFT) cell, which we can heat and connect to a gas delivery line, to analyze changes in surface functional groups.

Back to Top


Titrando A pH-Stat is usually used in analytical chemistry applications to titrate acid/base solutions, or metals. In the biointerface lab we use Titrando 902 (Metrohm, Fischer) to perform crystallization experiments in very controlled conditions. We have both a pH and a Ca sensitive electrode, which allow us to work in constant composition regimes, to mimic body conditions. A water-jacketed cell connected to a water bath allows us to keep the temperature constant as well. 

Back to Top

Ne200 Electrospinning Machine

Electrospinning Our electrospinning machine can produce nanofibers of various polymers. We use this instrument to prepare polymeric patches that can release anti-inflammatory drugs for skin diseases.

Back to Top